Deriving shape space parameters from immunological data.

  title={Deriving shape space parameters from immunological data.},
  author={Derek J. Smith and Stephanie Forrest and Ron R. Hightower and Alan S. Perelson},
  journal={Journal of theoretical biology},
  volume={189 2},
We present a method for deriving shape space parameters that are consistent with immunological data, and illustrate the method by deriving shape space parameters for a model of cross-reactive memory. Cross-reactive memory responses occur when the immune system is primed by one strain of a pathogen and challenged with a related, but different, strain. Much of the nature of a cross-reactive response is determined by the quantity and distribution of the memory cells, raised to the primary antigen… CONTINUE READING