Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches.

Abstract

Intermediate-resolution (7-9A) structures of large macromolecular complexes can be obtained by electron cryomicroscopy. This structural information, combined with bioinformatics data for the individual protein components or domains, can lead to a fold model for the entire complex. Such approaches have been demonstrated with the 6.8 A structure of the rice dwarf virus to derive models for the major capsid shell proteins.

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@article{Chiu2002DerivingFO, title={Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches.}, author={Wah Chiu and Matthew L. Baker and Wen Jiang and Z. Hong Zhou}, journal={Current opinion in structural biology}, year={2002}, volume={12 2}, pages={263-9} }