Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics

@article{Moore1996DerivingDO,
  title={Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics},
  author={Andrew Moore and H. J. McQuay and David J Gavaghan},
  journal={PAIN®},
  year={1996},
  volume={66},
  pages={229-237}
}
Reports of RCTs of analgesics frequently describe results of studies in the form of mean derived indices, rather than using discontinuous events--such as number or proportion of patients with 50% pain relief. Because mean data inadequately describe information with a non-normal distribution, combining mean data in systematic reviews may compromise the results. Showing that dichotomous data can reliably be derived from mean data, at least in acute pain models, indicates that more meaningful… CONTINUE READING

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