Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry.

@article{Faqehi2016DerivatizationOE,
  title={Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry.},
  author={Abdullah M. M. Faqehi and Diego F. Cobice and Gregorio Naredo and Tracy C-S Mak and Rita Upreti and Fraser Wilson Gibb and Geoffrey J. Beckett and Brian R. Walker and Natalie Z M Homer and Ruth Andrew},
  journal={Talanta},
  year={2016},
  volume={151},
  pages={148-156}
}
Estrogens circulate at concentrations less than 20pg/mL in men and postmenopausal women, presenting analytical challenges. Quantitation by immunoassay is unreliable at these low concentrations. Liquid chromatography tandem mass spectrometry (LC-MS/MS) offers greater specificity and sometimes greater sensitivity, but ionization of estrogens is inefficient. Introduction of charged moieties may enhance ionization, but many such derivatives of estrogens generate non-specific product ions… CONTINUE READING
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