Derivatives of 5,7,7-trimethyl-6-oxa-3-azatricyclo[]nonane with antiarrhythmic, local anesthetic and hypotensive activities.


The synthesis of ureas (IV) and amides (V) derived from the tricyclic terpenoid amine 5,7,7-trimethyl-6-oxa-3-azatricyclo[]nonane (III) is described. A number of these compounds showed hypotensive and bradycardic activity in rats, as well as infiltration anesthesia and antiarrhythmic activity in mice. In particular, the n-butylurea (IV b) was… (More)