Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.

Abstract

A series of 9-aminoalkanamido-1-azabenzanthrones derviatives (3a-i Ar-NHCO(CH(2))(n)NR(1)R(2)) and their quaternary methiodide salts (4a-g Ar-NHCO(CH(2))(n)N(+)(CH(3))R(1)R(2)I(-)) were designed and synthesized as acetylcholinesterase (AChE) or butyrylcholinesterase (BuChE) inhibitors. The synthetic compounds exhibited high AChE inhibitory activity with IC… (More)

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@article{Tang2007DerivativesOO, title={Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.}, author={Huang Tang and Fang-Xian Ning and Yong-Biao Wei and Shi-Liang Huang and Zhi-Shu Huang and Albert Sun-chi Chan and Lian-Quan Gu}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 13}, pages={3765-8} }