Derivatives of ColE1 cer show altered topological specificity in site-specific recombination.

@article{Summers1989DerivativesOC,
  title={Derivatives of ColE1 cer show altered topological specificity in site-specific recombination.},
  author={David K. Summers},
  journal={The EMBO journal},
  year={1989},
  volume={8 1},
  pages={309-15}
}
ColE1 contains a 250-bp sequence (cer) which is required in cis for the conversion of plasmid dimers to monomers. Recombination between cer and parB (a dimer resolution site from plasmid CloDF13) occurs in vivo at low frequency. The properties of the resulting hybrid sites have been studied. The type I hybrid closely resembles wild-type cer. It supports intramolecular recombination and requires the products of the chromosomal xerA, xerB and xerC genes together with the 250-bp site. In contrast… CONTINUE READING

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