Derivatives of 5-hydroxy-6-methyl-2-aminotetralin.

@article{Cannon1980DerivativesO5,
  title={Derivatives of 5-hydroxy-6-methyl-2-aminotetralin.},
  author={Joseph Gerard Cannon and D. L. Koble and John Paul Long and T. Verimer},
  journal={Journal of medicinal chemistry},
  year={1980},
  volume={23 7},
  pages={
          750-4
        }
}
The title compounds were designed to provide semirigid congeners of m-tyramine in which the ring position ortho to the phenolic OH is blocked to metabolic hydroxylation. A sequence leading to a key synthetic intermediate, 5-methoxy-6-methyl-2-tetralone, has been developed. In animal test models for dopamine-like effects, the title compounds demonstrated qualitative and quantitative differences from the isomeric 5-methyl-6-hydroxy-2-aminotetralins and from 5,6-dihydroxy-2-aminotetralins. Two of… 
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