Derivatives of α,β-dehydroamino acids: V. Intramolecular cyclization of 2-{2-[(Z)-1-Benzamido-2-phenylvinyl]acetamidomethyl}benzimidazole

@article{Topuzyan2009DerivativesO,
  title={Derivatives of α,β-dehydroamino acids: V. Intramolecular cyclization of 2-\{2-[(Z)-1-Benzamido-2-phenylvinyl]acetamidomethyl\}benzimidazole},
  author={Vigen Topuzyan and M. M. Kazandzhyan and Rafael A. Tamazyan and A. G. Aivazyan},
  journal={Russian Journal of Organic Chemistry},
  year={2009},
  volume={45},
  pages={215-217}
}
Reaction of 4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one with 2-(1H-benzimidazol-2-yl)ethaneamine led to the formation of 2-{2-[(Z)-1-benzamido-2-phenylvinyl]acetamidomethyl}benzimidazole that in a reaction with hexamethyldisilazane in DMF gave 5-benzylidene-1-(1H-benzimidazol-2-yl)-2-phenyl-3,5-dihydro-4H-imidazol-4-one. In the presence of K2CO3 in dioxane the reaction with hexamethyldisilazane resulted in the product of intramolecular addition, N-(4-benzyl-3-oxo-1,2,3,4-tetrahydropyrazino[1,2… CONTINUE READING