Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability.

@article{Huntly2002DerivativeC9,
  title={Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability.},
  author={Brian J. P. Huntly and Anthony J. Bench and Eric C M Delabesse and Alistair G. Reid and Juan Jenny Li and M. A. Scott and L. J. Campbell and Jennie Byrne and Eleanor M Pinto and Andr{\'e} Brizard and Deitger Niedermeiser and Elizabeth P. Nacheva and François Guilhot and Michael Werner Nikolaus Deininger and Anthony R Green},
  journal={Blood},
  year={2002},
  volume={99 12},
  pages={4547-53}
}
Deletions of the derivative chromosome 9 have recently been reported in chronic myeloid leukemia. These deletions are large, occur at the time of the Philadelphia (Ph) translocation, span the translocation breakpoint, and represent a powerful prognostic indicator. However, the molecular mechanisms responsible for the poor prognosis associated with deletions are obscure, and several possible models are investigated here. First, we demonstrate that all derivative chromosome 9 deletions detected… CONTINUE READING

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by guest www.bloodjournal.org From and p190 cause distinct leukemia in transgenic mice

J Voncken, V Kaartinen, +3 authors N BCRABLHeisterkamp
HUNTLY et al BLOOD, • 2002

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