Derivation of protein-specific pair potentials based on weak sequence fragment similarity.

@article{Skolnick2000DerivationOP,
  title={Derivation of protein-specific pair potentials based on weak sequence fragment similarity.},
  author={Jeffrey Skolnick and Andrzej Kolinski and Angel R. Ortiz},
  journal={Proteins},
  year={2000},
  volume={38 1},
  pages={
          3-16
        }
}
A method is presented for the derivation of knowledge-based pair potentials that corrects for the various compositions of different proteins. The resulting statistical pair potential is more specific than that derived from previous approaches as assessed by gapless threading results. Additionally, a methodology is presented that interpolates between statistical potentials when no homologous examples to the protein of interest are in the structural database used to derive the potential, to a Go… CONTINUE READING
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