Derivation of pluripotent epiblast stem cells from mammalian embryos

  title={Derivation of pluripotent epiblast stem cells from mammalian embryos},
  author={I. Gabrielle M. Brons and Lucy E. Smithers and Matthew W. Trotter and Peter J Rugg-Gunn and Bowen Sun and Susana M M Lopes and Sarah K. Howlett and Amanda Clarkson and Lars Ahrlund-Richter and Roger A. Pedersen and Ludovic Vallier},
Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago using feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other mammals, including both laboratory and domestic species, have been relatively unsuccessful. The most notable exceptions were the derivation of non-human primate ES cell lines followed shortly thereafter by their derivation of human ES cells. Despite the apparent common origin and the similar pluripotency of mouse and… CONTINUE READING
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