Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.

@article{Perez2012DerivationON,
  title={Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.},
  author={Silvia V Diaz Perez and Rachel Kim and Ziwei Li and Victor E. Marquez and Sanjeet G. Patel and Kathrin Plath and Amander T Clark},
  journal={Human molecular genetics},
  year={2012},
  volume={21 4},
  pages={
          751-64
        }
}
Human embryonic stem cells (hESCs) are pluripotent cell types derived from the inner cell mass of human blastocysts. Recent data indicate that the majority of established female XX hESC lines have undergone X chromosome inactivation (XCI) prior to differentiation, and XCI of hESCs can be either XIST-dependent (class II) or XIST-independent (class III). XCI of female hESCs precludes the use of XX hESCs as a cell-based model for examining mechanisms of XCI, and will be a challenge for studying X… CONTINUE READING

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