Derivation of attenuated porcine epidemic diarrhea virus (PEDV) as vaccine candidate.

@article{Kweon1999DerivationOA,
  title={Derivation of attenuated porcine epidemic diarrhea virus (PEDV) as vaccine candidate.},
  author={Chang Hee Kweon and Bae Ju Kwon and Jae Gun Lee and Geon Oh Kwon and Yew Beng Kang},
  journal={Vaccine},
  year={1999},
  volume={17 20-21},
  pages={
          2546-53
        }
}
The field isolate of porcine epidemic diarrhea virus (PEDV) was serially passaged in Vero cells. The cell passaged PEDV, designated KPEDV-9, was tested for its pathogenicity in the neonatal pigs, immunogenicity and safety in the pregnant sows. The result indicated that KPEDV-9 at the 93rd passage revealed reduced pathogenicity in the neonatal pigs. Pregnant sows inoculated with the attenuated virus showed increased immune responses by ELISA. In addition, delivered piglets were protected from… CONTINUE READING