Derivation of Huntington's disease-affected human embryonic stem cell lines.

@article{Bradley2011DerivationOH,
  title={Derivation of Huntington's disease-affected human embryonic stem cell lines.},
  author={Cara K. Bradley and Heather A. Scott and Omar Chami and Teija Tuulikki Peura and Biljana Dumevska and Uli Schmidt and Tomas Stojanov},
  journal={Stem cells and development},
  year={2011},
  volume={20 3},
  pages={495-502}
}
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of cytosine-adenine-guanine (CAG) repeats in the Huntingtin gene Htt. To facilitate research into HD, we have derived 4 human embryonic stem cell (hESC) lines containing ≥ 40 CAG repeats in exon 1 of Htt: SIVF017-HD (CAG₄₀), SIVF018-HD (CAG₄₆), SIVF020-HD (CAG₄₈), and SIVF046-HD (CAG₄₅). Additionally, we have derived a normal sibling-matched control for SIVF020-HD, cell line SIVF019. All 5 hESC… CONTINUE READING

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