Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.

@article{Alexander1997DerivationOH,
  title={Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.},
  author={Jeff Alexander and Carla Oseroff and John Sidney and Paul Wentworth and Elissa Keogh and Gary Hermanson and Francis V. Chisari and Ralph T. Kubo and Howard Grey and Alessandro Sette},
  journal={Journal of immunology},
  year={1997},
  volume={159 10},
  pages={4753-61}
}
Transgenic mice expressing chimeric human (alpha1 and alpha2 HLA-A11 domains) and murine (alpha3, transmembrane, and cytoplasmic H-2Kb domains) class I molecules were derived. These mice were used as a model system to study the immunogenicity of human CTL epitopes and also to examine the aspects of Ag processing differences of mice vs man. Immunization of these mice with seven known HLA-A11-restricted CTL epitopes emulsified in IFA resulted in vigorous specific CTL responses. A larger panel of… CONTINUE READING