Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for control.

@article{Thurley2011DerivationOC,
  title={Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for control.},
  author={Kevin Thurley and Martin Falcke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 1},
  pages={427-32}
}
Ca(2+) is a universal second messenger in eukaryotic cells transmitting information through sequences of concentration spikes. A prominent mechanism to generate these spikes involves Ca(2+) release from the endoplasmic reticulum Ca(2+) store via inositol 1,4,5-trisphosphate (IP(3))-sensitive channels. Puffs are elemental events of IP(3)-induced Ca(2+) release through single clusters of channels. Intracellular Ca(2+) dynamics are a stochastic system, but a complete stochastic theory has not been… CONTINUE READING

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