Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.

@article{Tomoda2012DerivationCI,
  title={Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.},
  author={Kiichiro Tomoda and Kazutoshi Takahashi and Karen Ming-Lam Leung and Aki Okada and Megumi Narita and Nazumi Alice Yamada and Kirsten E. Eilertson and Peter W. K. Tsang and Shiro Baba and Mark P. White and Salma Sami and Deepak Srivastava and Bruce R. Conklin and Barbara Panning and Shinya Yamanaka},
  journal={Cell stem cell},
  year={2012},
  volume={11 1},
  pages={91-9}
}
Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one inactive X (Xi) chromosome from donor cells. However, at low frequency, hiPSC lines with two Xas are produced, suggesting that epigenetic alterations of the Xi occur sporadically during reprogramming. We show here that X-inactivation status in female hiPSC lines depends on derivation conditions. hiPSC lines… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS