Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.

Abstract

The lack of rat embryonic stem cells (ESCs) and approaches for manipulation of their genomes have restricted the ability to create new genetic models and to explore the function of a single gene in complex diseases in the laboratory rat. The recent breakthrough in isolating germline-competent ESCs from rat and subsequent demonstration of gene knockout has… (More)
DOI: 10.1089/scd.2012.0416

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