Derivation and function of small interfering RNAs and microRNAs.

  title={Derivation and function of small interfering RNAs and microRNAs.},
  author={Bryan R Cullen},
  journal={Virus research},
  volume={102 1},
Small interfering RNA (siRNA) duplexes are generally produced by Dicer cleavage of double-stranded RNAs of frequently exogenous origin and can induce the cleavage and degradation of mRNAs bearing an identical sequence. In contrast, microRNAs (miRNAs) are encoded within the eukaryotic genome as short RNA hairpin structures. While these pre-miRNAs are also processed by Dicer, mature miRNAs appear to function primarily by inhibiting the translation of mRNAs bearing multiple, partially mismatched… CONTINUE READING

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