Derepression of RNA polymerase III transcription by phosphorylation and nuclear export of its negative regulator, Maf1.

@article{Towpik2008DerepressionOR,
  title={Derepression of RNA polymerase III transcription by phosphorylation and nuclear export of its negative regulator, Maf1.},
  author={Joanna Towpik and Damian Graczyk and Anna Gajda and Olivier Lefebvre and Magdalena Boguta},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 25},
  pages={17168-74}
}
Maf1 is the global repressor of RNA polymerase III (Pol III) in yeast Saccharomyces cerevisiae. Transcription regulation by Maf1 is important under stress conditions and during the switch between fermentation and respiration. Under repressive conditions on nonfermentable carbon sources, Maf1 is dephosphorylated and located predominantly in the nucleus. When cells were shifted to glucose medium, Maf1 became phosphorylated and concomitantly relocated to the cytoplasm. This relocation was… CONTINUE READING

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