Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype.

@article{Seidl2016DerepressionOM,
  title={Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype.},
  author={Christine I Seidl and Aida Martinez-Sanchez and Christopher L. Murphy},
  journal={Arthritis & rheumatology},
  year={2016},
  volume={68 2},
  pages={
          398-409
        }
}
OBJECTIVE To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs). METHODS The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes were identified and verified by overexpression of synthetic miRNA mimics and inhibitors, luciferase assays, chromatin immunoprecipitation, and RNA immunoprecipitation of native… CONTINUE READING

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