Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

@article{AguirreGhiso1999DeregulationOT,
  title={Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.},
  author={J A Aguirre Ghiso and Daniel Fernando Alonso and Eduardo F. Far{\'i}as and Daniel Eduardo Gomez and Elisa D Bal de Kier Joff{\'e}},
  journal={European journal of biochemistry},
  year={1999},
  volume={263 2},
  pages={
          295-304
        }
}
We review the evidence in support of the notion that, upon experimental oncogenic transformation or in spontaneous human cancers, mitogenesis and expression of urokinase (uPA) and its receptor (uPAR) are activated through common signaling complexes and pathways. It is well documented that uPA, uPAR or metalloproteinases (MMPs) are overexpressed in tumor cells of mesenchymal or epithelial origin and these molecules are required for tumor invasion and metastasis. Furthermore, oncogenic stimuli… Expand
Urokinase/Urokinase Receptor-Mediated Signaling in Cancer
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