Deregulation of the cell cycle by breast tumor kinase (Brk).

Abstract

Brk is a cytoplasmic nonreceptor tyrosine kinase that is overexpressed in breast tumors but undetectable in normal or benign mammary tissues. Brk promotes proliferation of human mammary epithelial cells and tumor growth in a mouse model, but the role of Brk in cell cycle regulation is not known. In this study, we describe the mechanism of Brk-induced… (More)
DOI: 10.1002/ijc.25263

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@article{Chan2010DeregulationOT, title={Deregulation of the cell cycle by breast tumor kinase (Brk).}, author={Edward K L Chan and Anjaruwee S. Nimnual}, journal={International journal of cancer}, year={2010}, volume={127 11}, pages={2723-31} }