Deregulation of the arginine deiminase (arc) operon in penicillin-tolerant mutants of Streptococcus gordonii.

@article{Caldelari2000DeregulationOT,
  title={Deregulation of the arginine deiminase (arc) operon in penicillin-tolerant mutants of Streptococcus gordonii.},
  author={I Caldelari and B Loeliger and H. Hans Langen and Michel Pierre Glauser and Philippe Moreillon},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 10},
  pages={2802-10}
}
Penicillin tolerance is an incompletely understood phenomenon that allows bacteria to resist drug-induced killing. Tolerance was studied with independent Streptococcus gordonii mutants generated by cyclic exposure to 500 times the MIC of penicillin. Parent cultures lost 4 to 5 log(10) CFU/ml of viable counts/24 h. In contrast, each of four independent mutant cultures lost < or =2 log(10) CFU/ml/24 h. The mutants had unchanged penicillin-binding proteins but contained increased amounts of two… CONTINUE READING

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