Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

@inproceedings{Yamamoto2014DeregulationOT,
  title={Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14},
  author={Kazuhiro Yamamoto and Takahiro Seki and Hikaru Yamamoto and Naoko Adachi and Shigeru Tanaka and Izumi Hide and Naoaki Saito and Norio Sakai},
  booktitle={Front. Physiol.},
  year={2014}
}
Several missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. γPKC is a neuron-specific member of the classical PKCs and is activated and translocated to subcellular regions as a result of various stimuli, including diacylglycerol synthesis, increased intracellular Ca(2+) and phorbol esters. We investigated whether SCA14 mutations affect the γPKC-related functions by stimulating… CONTINUE READING
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Protein kinase C modulates synaptic vesicle acidification

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Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

  • K Citation Yamamoto, T Seki, +5 authors N Sakai
  • Front. Physiol. 5:126
  • 2014

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums

  • Yamamoto, Seki, +4 authors Sakai
  • section of the journal Frontiers in Physiology
  • 2014

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