Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma.

@article{LpezGuerrero2004DeregulationOT,
  title={Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma.},
  author={J{\'o}se Antonio L{\'o}pez-Guerrero and Concha L{\'o}pez-Gin{\'e}s and Antonio Pell{\'i}n and C. Carda and Antonio Llombart-Bosch},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2004},
  volume={13 2},
  pages={
          81-91
        }
}
Osteosarcoma (OS) displays complex karyotypes with numerical changes as well as structural abnormalities suggesting that several oncogenes and tumor suppressor genes may be implicated in the biology of OS. The aim of our study was to investigate the possible implication of the molecular alterations of the G1 to S-phase checkpoint genes in the pathogenesis of OS. We analyzed samples from 29 patients and found molecular alterations of the RB and TP53 genes in 6 (21%) and 3 (10%) cases… CONTINUE READING
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