Deregulation of microRNAs in myelodysplastic syndrome

  title={Deregulation of microRNAs in myelodysplastic syndrome},
  author={Garrett W Rhyasen and Daniel T. Starczynowski},
Myelodysplastic syndromes (MDSs) consist of a family of hematopoietic stem cell (HSC) disorders characterized by ineffective differentiation of hematopoietic progenitors, bone marrow dysplasia, genetic instability and a propensity to develop acute myeloid leukemia. The development of MDS is poorly understood and therefore, effective treatment options are limited. Recent progress has been made in identifying altered signaling pathways and understanding the HSC defects, which are thought to… CONTINUE READING
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NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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