Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia.

@article{Caporali2011DeregulationOM,
  title={Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia.},
  author={Andrea Caporali and Marco M. Meloni and Christine Voellenkle and D{\'e}sir{\'e}e Bonci and Graciela B. Sala-Newby and Roberta Addis and G Spinetti and Sergio Losa and Rachel Masson and Andrew H. Baker and Reuven Agami and Carlos le Sage and Gianluigi Condorelli and Paolo Madeddu and Fabio Martelli and Costanza Emanueli},
  journal={Circulation},
  year={2011},
  volume={123 3},
  pages={282-91}
}
BACKGROUND Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood. microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region. METHODS AND RESULTS We found that microRNA-503 (miR-503) expression in… CONTINUE READING