Deregulation of erythropoiesis by the Friend spleen focus-forming virus.

  title={Deregulation of erythropoiesis by the Friend spleen focus-forming virus.},
  author={Sandra K. Ruscetti},
  journal={The international journal of biochemistry & cell biology},
  volume={31 10},
The proliferation and differentiation of erythroid cells is a highly regulated process that is controlled primarily at the level of interaction of erythropoietin (Epo) with its specific cell surface receptor (EpoR). However, this process is deregulated in mice infected with the Friend spleen focus-forming virus (SFFV). Unlike normal erythroid cells, erythroid cells from SFFV-infected mice are able to proliferate and differentiate in the absence of Epo, resulting in erythroid hyperplasia and… CONTINUE READING


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