Deregulation of common genes by c-Myc and its direct target, MT-MC1.

  title={Deregulation of common genes by c-Myc and its direct target, MT-MC1.},
  author={Kenneth R. Rogulski and Debra E Cohen and David L. Corcoran and Panayiotis V. Benos and Edward V. Prochownik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 52},
In addition to its role in cancer, the c-Myc oncoprotein controls many normal cellular processes as a consequence of its function as a basic helix-loop-helix leucine zipper transcription factor. Determining which of the myriad genes under c-Myc control are relevant for these various roles is thus a major challenge. mt-mc1 is a direct c-Myc target gene whose overexpression recapitulates multiple c-Myc phenotypes, including transformation. Using transcriptional profiling, we now show that MT-MC1… CONTINUE READING
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Development (Cambridge, U.K

  • J. Z. Maines, L. M. Stevens, X. Tong, D. Stein
  • 2004

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