Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis

@inproceedings{Tognon2012DeregulationOA,
  title={Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis},
  author={Raquel Tognon and Elainy PL Gasparotto and Renata Peres Neves and Nat{\'a}lia de Souza Nunes and Aline F Ferreira and Patricia V. B. Palma and Simone Kashima and Dimas Tadeu Covas and Mary Santana and Elizabeth Xisto Souto and Maria Aparecida Zanichelli and Belinda Pinto Sim{\~o}es and Ana Maria Medeiros de Souza and Fab{\'i}ola Atti{\'e} de Castro},
  booktitle={Journal of hematology & oncology},
  year={2012}
}
BACKGROUND Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. The JAK2 V617F mutation and PRV1 gene overexpression may contribute to MPN physiopathology. We hypothesized that deregulation of the… CONTINUE READING