Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy

Abstract

Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy. Respiratory failure causes death in SMA but the underlying molecular mechanism is unknown. The zinc finger protein ZPR1 interacts with SMN. ZPR1 is down regulated in SMA patients. We report… (More)
DOI: 10.1038/s41598-017-07603-z

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