Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.

@article{Zhang2009DeregulationOT,
  title={Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.},
  author={Minying Zhang and Wei Jin and Xiaofei Zhou and Jiayi Yu and Andrew Joon Lee and Shao-cong Sun},
  journal={Cellular signalling},
  year={2009},
  volume={21 4},
  pages={559-66}
}
Lithium is an anti-depressant drug that also possesses immunomodulatory functions. The anti-inflammatory effect of lithium is thought to involve activation of the transcription factor CREB, although the underlying mechanism is incompletely understood. We show here that in macrophages lithium stimulates Tpl2, a MAP kinase kinase kinase (MAP3K) known to mediate activation of extracellular signal regulated kinase (ERK) and the downstream target CREB. Lithium activates Tpl2 by inducing degradation… CONTINUE READING

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