Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis.

@article{Tseng2015DeregulationOS,
  title={Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis.},
  author={Ruo-Chia Tseng and Jia-Ming Chang and Jeng-Hung Chen and Way-Ren Huang and Yen-An Tang and I-Ying Kuo and Jing-jou Yan and Wu-Wei Lai and Yi-Ching Wang},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2015},
  volume={10 1},
  pages={
          189-98
        }
}
INTRODUCTION SLIT2, a secreted protein, has been found to inactivate Cdc42 GTPase to modulate neural cell migration. However, alteration of SLIT2-mediated Cdc42 in terms of migration regulation remains undefined in esophageal squamous cell carcinoma (ESCC). METHODS We report here in ESCC cell, animal, and clinical models that SLIT2 acts as a migration suppressor and serves as a prognostic biomarker. RESULTS The immunohistochemistry data indicated that 31.8% (49 of 154) of tumors from ESCC… CONTINUE READING
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