Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.

@article{Dadke2006DeregulationOH,
  title={Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.},
  author={Disha Dadke and Michael Jarnik and Elena N. Pugacheva and Mahendra K. Singh and Erica A Golemis},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 3},
  pages={
          1204-17
        }
}
The focal adhesion-associated signaling protein HEF1 undergoes a striking relocalization to the spindle at mitosis, but a function for HEF1 in mitotic signaling has not been demonstrated. We here report that overexpression of HEF1 leads to failure of cells to progress through cytokinesis, whereas depletion of HEF1 by small interfering RNA (siRNA) leads to defects earlier in M phase before cleavage furrow formation. These defects can be explained mechanistically by our determination that HEF1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

migration : a physically integrated molecular process

  • S. F. Law, J. Estojak, B. Wang, T. Mysliwiec, G. D. Kruh, E. A. Golemis
  • Cell
  • 1996
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…