Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma.

@article{Bonetti2013DeregulationOE,
  title={Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma.},
  author={Paola Bonetti and Monica Testoni and Marta Scandurra and Maurilio A. Ponzoni and Roberto Piva and Afua Adjeiwaa Mensah and Andrea Rinaldi and Ivo Kwee and Maria Grazia Tibiletti and Javeed Iqbal and Timothy Greiner and Wing-Chung C Chan and Gianluca Gaidano and Miguel {\'A}ngel Piris and Franco Cavalli and Emanuele Zucca and Giorgio Inghirami and Francesco Bertoni},
  journal={Blood},
  year={2013},
  volume={122 13},
  pages={
          2233-41
        }
}
Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. DLBCL is a heterogeneous disease characterized by different genetic lesions. We herein report the functional characterization of a recurrent gain mapping on chromosome 11q24.3, found in 23% of 166 DLBCL cases analyzed. The transcription factors ETS1 and FLI1, located within the 11q24.3 region, had significantly higher expression in clinical samples carrying the gain. Functional studies on cell lines showed that… CONTINUE READING
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