Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression.

@article{Netchiporouk2014DeregulationIS,
  title={Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression.},
  author={Elena Netchiporouk and Ivan V Litvinov and Linda Moreau and Martin Gilbert and Denis Sasseville and Madeleine Duvic},
  journal={Cell cycle},
  year={2014},
  volume={13 21},
  pages={3331-5}
}
Deregulation of STAT signaling has been implicated in the pathogenesis for a variety of cancers, including CTCL. Constitutive activation of STAT5 and STAT3 was observed in early and late stages of CTCL, respectively. In early stages, IL-2, IL-7 and IL-15 signaling via JAK1 and JAK3 kinases is believed to be responsible for activating STAT5, while in advanced stages development of IL-21 autocrine signaling is thought to be important for STAT3 activation. Recent molecular evidence further… CONTINUE READING