Deregulated transcription factors in leukemia

@article{Shima2011DeregulatedTF,
  title={Deregulated transcription factors in leukemia},
  author={Yutaka Shima and Issay Kitabayashi},
  journal={International Journal of Hematology},
  year={2011},
  volume={94},
  pages={134-141}
}
Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal… CONTINUE READING

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