Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.

@article{Lagunoff1999DeregulatedST,
  title={Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.},
  author={Michael Lagunoff and R Majeti and Arthur Weiss and Donald E Ganem},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 10},
  pages={5704-9}
}
The Kaposi's sarcoma (KS)-associated herpesvirus is a lymphotropic virus strongly implicated in the pathogenesis of KS and several lymphoproliferative disorders. The KS-associated herpesvirus K1 gene encodes a transmembrane protein bearing a functional immunoreceptor tyrosine-based activation motif (ITAM)-like sequence; it previously has been proposed to be important in viral tumorigenesis because its expression can trigger cell proliferation in vitro and in vivo. Here we show that expression… CONTINUE READING
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