Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression.

@article{Eichelser2013DeregulatedSC,
  title={Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression.},
  author={Corinna Eichelser and Dieter Flesch-Janys and Jenny Chang-Claude and Klaus Pantel and Heidi Schwarzenbach},
  journal={Clinical chemistry},
  year={2013},
  volume={59 10},
  pages={1489-96}
}
BACKGROUND MicroRNAs (miRs) are small, noncoding RNAs that target genes involved in tumor development and progression. In the current study, we investigated the use of circulating miR concentrations as biomarkers in the serum of breast cancer patients. METHODS We analyzed serum samples from 120 patients with primary breast cancer after surgery and before chemotherapy (M0, classified into 3 subgroups of 40 patients with progesterone/estrogen-positive, HER2-positive, and triple-negative cancer… CONTINUE READING
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