Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

Abstract

The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is regulated by phosphorylation — through the activity of cyclin-dependent kinases (CDKs) — and protein degradation, which occurs through ubiquitin ligases such as SCF (SKP1–CUL1–F-box protein) complexes and APC/C (anaphase-promoting… (More)
DOI: 10.1038/nrc2396

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Cite this paper

@article{Frescas2008DeregulatedPB, title={Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer}, author={David Frescas and M. Pagano}, journal={Nature Reviews Cancer}, year={2008}, volume={8}, pages={438-449} }