Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3.

@article{Wang2011DeregulatedMP,
  title={Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3.},
  author={Hai-Qiang Wang and Xiao-Dong Yu and Zhi-heng Liu and Xin Cheng and Dino Samartzis and L Jia and Sheng-xi Wu and Jing Huang and Jing Chen and Zhuojing Luo},
  journal={The Journal of pathology},
  year={2011},
  volume={225 2},
  pages={232-42}
}
The role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains enigmatic. Accumulating evidence has shown that the apoptotic machinery is regulated by miRNAs. We hypothesized that miRNAs might contribute to apoptosis in IDD. We have found that 29 miRNAs were differentially expressed and miR-155 was down-regulated in degenerative… CONTINUE READING