Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

@article{Ogawa2010DeregulatedIS,
  title={Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.},
  author={Seishi Ogawa and Lee-Yung Shih and Takahiro Suzuki and Makoto Otsu and Hiromitsu Nakauchi and H Phillip Koeffler and Masashi Sanada},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 15},
  pages={
          3825-31
        }
}
c-CBL encodes a 120-kDa protein involved in intracellular signal transduction in a wide variety of cell types. Recently, frequent mutations of c-CBL have been reported in myeloid neoplasms showing both myelodysplastic and myeloproliferative features, in which most mutations are present in a homozygous state, as a result of allelic conversion in 11q. c-CBL has ubiquitin E3 ligase activity for a wide variety of tyrosine kinases, and thereby, negatively regulates tyrosine kinase signaling… CONTINUE READING

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