Deregulated inflammasome signaling in disease.

  title={Deregulated inflammasome signaling in disease.},
  author={Mohamed Lamkanfi and Lieselotte Vande Walle and Thirumala-Devi Kanneganti},
  journal={Immunological reviews},
  volume={243 1},
Inflammasomes are multi-protein complexes that sense microbial molecules and endogenous danger signals in intracellular compartments. Inflammasome assembly results in caspase-1 activation, which in turn drives maturation and secretion of the pro-inflammatory cytokines interleukin 1β (IL-1β) and IL-18, and induces pyroptosis to eliminate the infectious agent. The importance of inflammasomes in regulating immune responses was recognized with the discovery of polymorphisms in genes encoding… CONTINUE READING


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