Deregulated expression of c-Myc depletes epidermal stem cells

  title={Deregulated expression of c-Myc depletes epidermal stem cells},
  author={Rebekah L. Waikel and Yasuhiro Kawachi and Patricia A. Waikel and Xiao-Jing Wang and Dennis R. Roop},
  journal={Nature Genetics},
The β-catenin/TCF signaling pathway is essential for the maintenance of epithelial stem cells in the small intestine. c-Myc a downstream target of β-catenin/TCF (ref. 2), can induce differentiation of epidermal stem cells in vitro. To determine the role of c-Myc in epidermal stem cells in vivo, we have targeted expression of human MYC2 to the hair follicles and the basal layer of mouse epidermis using a keratin 14 vector (K14.MYC2). Adult K14.MYC2 mice gradually lose their hair and develop… CONTINUE READING
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