Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc

@article{Kurabe2007DeregulatedEO,
  title={Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc},
  author={Nobuya Kurabe and Kumiko Katagiri and Yuko Komiya and Ryoutaro Ito and Akinori Sugiyama and Yoshihiro Kawasaki and Fumio Tashiro},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={5626-5634}
}
c-Myc N-terminal conserved domains, MbI and MbII, are essential for c-Myc-mediated transformation and transactivation. These domains recruit the STAGA (SPT3-TAF9-GCN5-acetyltransferase) coactivator complex, but not TFTC (TATA-binding protein-free TAF-containing) to the target gene promoter. Although components of this complex are well conserved between yeast and mammals, four mammalian orthologs of yeast SPT8, SPT20, SGF11 and SGF29 remain to be identified. Here, we isolated a rat ortholog of… CONTINUE READING