Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.

@article{Lukas1996DeregulatedEO,
  title={Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.},
  author={Josef Lukas and Birgit Otzen Petersen and Karin Holm and Jiri Bartek and Kristian Helin},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 3},
  pages={
          1047-57
        }
}
The E2F family of transcription factors regulate genes, whose products are essential for progression through the mammalian cell cycle. The transcriptional activity of the E2Fs is inhibited through the specific binding of the retinoblastoma protein, pRB, and the pRB homologs p107 and p130 to their transactivation domains. Seven members of the E2F transcription factor family have been isolated so far, and we were interested in investigating the possible contribution of the various E2Fs to cell… CONTINUE READING

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