Deregulated expression of DNA polymerase β is involved in the progression of genomic instability.

  title={Deregulated expression of DNA polymerase β is involved in the progression of genomic instability.},
  author={Qingying Luo and Yanhao Lai and Shukun Liu and Mei Wu and Yuan Hua Liu and Zunzhen Zhang},
  journal={Environmental and molecular mutagenesis},
  volume={53 5},
Deregulated expression of DNA polymerase beta (pol β) has been implicated in genomic instability that leads to tumorigenesis, yet the mechanisms underlying the pol β-mediated genetic instability remain elusive. In this study, we investigated the roles of deregulated expression of pol β in spontaneous and xenobiotic-induced genetic instability using mouse embryonic fibroblasts (MEFs) that express distinct pol β levels (wild-type, null, and overexpression) as a model system. Three genetic… CONTINUE READING

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