Deregulated c-fos augments the expression of IL-2 gene in T cells stimulated with anti-CD3 antibody.

  • Yukari Ochi
  • Published 1992 in The Kobe journal of medical sciences

Abstract

The expression of IL-2 gene in T cells stimulated with immobilized anti-CD3 antibody is controlled by several transcription factors like as AP-1, IL-2 kappa B and NFAT. We studied an effect of deregulated c-fos, a component of AP-1, in the expression of IL-2 gene in T cells by using splenic T cells from transgenic mice carrying the exogenous c-fos gene… (More)

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